Restaurant chain Six by Nico is to open at the former record store Fopp on February 27.
Chef proprietor Nico Simeone took to social media this week to confirm the new venue would be opening.
The premises has not had a permanent tenant since Fopp closed three years ago.
The legendary record shop was a firm fixture on the street and its loss was widely lamented.
The first floor was occupied by pizzeria Santa Lucia and later a deli.
But Six by Nico signals a new lease of life for the building at a tough time economically for the High Street - and households.
Nico floated his plans two years ago but work seemed to have stalled.
The chef announced the opening in a video on his Facebook page this week.
"Hey, Guys, I can't wait to bring Six by Nico to Byres Road at the end of February.
"Please let me know what menu you would like to see first," he said in a short reel.
The proposals when first announced were for all floors of the premises to be occupied.
Hey, Guys, I can't wait to bring Six by Nico to Byres Road at the end of February. Please let me know what menu you would like to see first.
Planning papers said: "The intention for the site is to create one ownership with three facilities within, including - fine dining restaurant, bar and roof top bar with dining.
"The roof top bar will be screened with glass and aluminium construction to act as acoustic barriers.
"The open area is also to be set back from the Byres Road elevation to reduce the risk of noise leakage affecting the flats opposite."
Details on the final layout are not clear but it won't be long before we find out.
In recent years, the premises has had various pop-up uses from a cheese shop and candle shop to a collection point for charity Refuweegee.
Glasgow-based Six By Nico currently has two other restaurants in the Southside on Nithsdale Road, and on Argyle Street in Finnieston.
In recent years, the chain has expanded to other cities including London, Belfast, Manchester and Aberdeen.